Publications and Presentations by Human Proteomics Program (HPP) Staff and Users with the Data Acquired at HPP Mass Spectrometry Facility
Publications: (*Corresponding authors)
- Zabrouskov, V.; Ge, Y.*; Schwartz, J.; Walker, J. W.* Unraveling molecular complexity of phosphorylated human cardiac troponin I by top down electron capture dissociation/electron transfer dissociation mass spectrometry, Mol. Cell. Proteomics, 2008, 7, 1838-1849.
- Berndsen, C.E.; Tsubota, T.; Lindner, S.E.; Lee, S.; Holton, J.M.; Kaufman, P.D.; Keck, J.L.; Denu, J.M.* Molecular functions of the histone acetyltransferase chaperone complex Rtt109-Vps75. Nat. Struct. Mol. Biol. 2008, 15, 948-956.
- Lee, S.; Tong, L.; Denu, J.M.* Quantification of endogenous sirtuin metabolite O-Acetyl-ADP-Ribose (OAADPR). Anal. Biochem. 2008, 383, 174-179.
- Sancho Solis, R.; Ge, Y.; Walker, J. W.* Single amino acid sequence polymorphisms in rat cardiac troponin revealed by top-down tandem mass spectrometry, J. Muscle Res. Cell Motil. 2008, 29, 203-212.
- Ma, M.; Chen, R.; Ge, Y.; He, H; Marshall, A. G.; Li, L.* Combining bottom-up and top-down mass spectrometric strategies for de novo sequencing of the Crustacean hyperglycemic hormone (CHH) from Cancer borealis, Anal. Chem. 2009, 81, 240-247.
- Wei, X.; Herbst, A.; Schmidt, J.; Aiken, J.; Li, L.* Facilitating discovery of prion disease biomarkers by quantitative glycoproteomics. LCGC, 2009 [Invited technical article, Accepted, to be appeared in March 2009 issue].
- Kuhn, P.; Xu, Q.; Cline, E.; Zhang, D.; Ge, Y.*; Xu, W.* Delineating Anopheles gambiae coactivator associated arginine methyltransferase 1 (AgCARM1) by top-down high resolution tandem mass spectrometry, Protein Sci. 2009, 18, 1272-1280.
- Liu, L.; Hou, J.; Du, J.; Chumanov, R. S. ; Xu, Q.; Ge, Y.; Johnson, J.A.; Murphy, R.M. Differential modification of Cys10 alters transthyretin’s effect on beta-amyloid aggregation and toxicity, Protein Eng. Des. Sel. 2009, 1–10.
- Ge, Y.*; Rybakova, I.; Xu, Q.; Moss, R. L. Top-down high resolution mass spectrometry of cardiac myosin binding protein C revealed that truncation alters protein phosphorylation state, Proc. Natl. Acad. Sci. U. S. A. 2009, Epub ahead of print.
- Ayaz-Guner, S.; Zhang, J.; Li, L.; Walker, J. W.*; Ge, Y.* In Vivo Phosphorylation Site Mapping in Mouse Cardiac Troponin I by High Resolution Top-Down Electron Capture Dissociation Mass Spectrometry: Ser22/23 Are the Only Sites Basally Phosphorylated, Biochemistry, 2009 Epub ahead of print.
Selected Presentations:
- Ge, Y.; Zhao, D.; Gu, X.; Lemoff, A.S.; Ding, X. Rapid determination of disulfide bonds in large proteins by top down liquid chromatography tandem mass spectrometry, 54th Conf. Mass Spectrom. Allied Topics, Seattle, WA, 2006 (Poster Presentation)
- Ge, Y.; Walker, J.W.; Gumerov, D.R.; Easterling M.L.; Speir, J.P. Localization of phosphorylation sites in human cardiac troponin I by top down electron capture dissociation mass spectrometry, HUPO 5th World Congress, Long Beach, CA, 2006 (Oral Presentation)
- Ge, Y.; Zabrouskov, V.; Walker, J.W. Top Down Electron Capture Dissociation Mass Spectrometry for Characterization and Quantitative Determination of Phosphorylation in Human Cardiac Troponin I 6th NORTH AMERICAN FT-ICR MS CONFERENCE, Lake Tahoe, CA, 2007 (Poster Presentation).
- Zabrouskov, V.; Ge, Y.; Schwartz, J.; Walker, J.W. Unraveling molecular complexity of phosphorylated human cardiac troponin I by top down electron capture dissociation/electron transfer dissociation mass spectrometry HUPO 6th World Congress, Seoul, Korea, 2007 (Poster Presentation)
- Wei, X.; Schmidt, J. A. Herbst, Aiken, J.; L. Li, Comparative glycoproteomics for the discovery of potential biomarkers for prion disease, 55th Conf. Mass Spectrom. Allied Topics, Indianapolis, IN, 2007, (Poster Presentation)
- Wei, X.; Schmidt, J.J.; Herbst, A.; Aiken, J.; Li, L. MS-based comparative profiling of glycoproteins for the discovery of potential biomarkers for prion disease, PittCon 2007, Chicago, IL (Poster Presentation)
- Ge, Y.; Xu, L.; Rybakova, I.; Zabrouskov, V.; Moss, R.L.; Walker, J.W. Top Down Disease Proteomics: Deciphering Protein Modifications for Understanding and Diagnosis of Human Diseases, 56th Conf. Mass Spectrom. Allied Topics, Denvor, CO, 2008 (Oral Presentation)
- L. Li, X. Wei, A. Herbst, S. McIlwain, J. Schmidt, R. Cunningham, D. Page, and J. Aiken, “Combining MALDI FTMS, comparative glycoproteomics, and bioinformatics for the discovery of biomarkers in prion disease,” 56th Conf. Mass Spectrom. Allied Topics, Denver, CO. 2008. (Oral Presentation)
- M. Ma, J. Schmidt, Y. Ge, L. Li, Mass spectrometric characterization of the crustacean hyperglycemic hormone (CHH) in the sinus gland of Cancer borealis, 56th Conf. Mass Spectrom. Allied Topics, Denver, CO. 2008, (Oral Presentation)
- Xu, W. CARM1: modifications and functions, FASEB summer conference, Carefree, AZ, 2008. (Oral Presentation)
- Kuhn, P.; Xu, Q.; Cline, E.; Zhang, D.; Ge, Y.; Xu, W. Investigation of CARM1 automethylation by Top-Down Mass Spectrometry, Molecular Basis for Chromatin Modifications and Epigenetic Phenomena, Snowmass, Colorado, 2008. (Poster Presentation)
- Ge, Y. Top Down Disease Proteomics for Protein Biomarker Discovery and Validation, 6th Annual Protein Biomarker Summit, Philadelphia, PA, 2008. (Invited Oral Presentation)
- Ge, Y.; Zhang, J.; Ayaz-Guner, S.; Xu, Q.; Rybakova, I.; Guy, M.; Young, K. H.; Walker, J. W.; Moss, R. L. Top-down disease proteomics: deciphering myofilament protein modifications for understanding heart failure. ISHR North American Section Meeting, Baltimore, ML, 2009.
- Nelson, C. A.; Szezech, J. R.; Xu, Q.; Jin, S.; Ge, Y. Mesoporous Metal Oxide Nanomaterials for Mass Spectrometry-based Phosphoproteomics, 57th Conf. Mass Spectrom. Allied Topics, Philadelphia, PA, 2009.
- Zhang, J.; Guy, M.; Xu, Q.; Salamat, M.S.; Young, K. H.; Walker, J. W.; Ge, Y. Deciphering Human Cardiac Troponin Modifications for Understanding and Diagnosis of Heart Failure: A Top-Down Mass Spectrometry-Based Disease Proteomics Approach, 57th Conf. Mass Spectrom. Allied Topics, Philadelphia, PA, 2009.
- Ayaz-Guner, S.; Doede, C.; Walker, J.W.; Ge, Y.Top-Down High Resolution Electron Capture Dissociation Mass spectrometry for Characterization of Post-Translational Modifications in Mouse Cardiac Troponin, 57th Conf. Mass Spectrom. Allied Topics, Philadelphia, PA, 2009.
- Kuhn, P.; Xu, Q.; Cline, E.; Zhang, D.; Ge, Y.; Xu, W. Top-down High Resolution Tandem Mass Spectrometry for Characterization of Conserved Automethylation in Coactivator Associated Arginine Methyltransferase 1, 57th Conf. Mass Spectrom. Allied Topics, Philadelphia, PA, 2009.