Publications and Presentations by Human Proteomics Program (HPP) Staff and Users with the Data Acquired at HPP Mass Spectrometry Facility

Publications: (*Corresponding authors)

  1. Zabrouskov, V.; Ge, Y.*; Schwartz, J.; Walker, J. W.* Unraveling molecular complexity of phosphorylated human cardiac troponin I by top down electron capture dissociation/electron transfer dissociation mass spectrometry, Mol. Cell. Proteomics, 2008, 7, 1838-1849.

  2. Berndsen, C.E.;  Tsubota, T.; Lindner, S.E.;  Lee, S.; Holton, J.M.; Kaufman, P.D.; Keck, J.L.; Denu, J.M.* Molecular functions of the histone acetyltransferase chaperone complex Rtt109-Vps75. Nat. Struct. Mol. Biol. 2008, 15, 948-956.

  3. Lee, S.; Tong, L.; Denu, J.M.* Quantification of endogenous sirtuin metabolite O-Acetyl-ADP-Ribose (OAADPR). Anal. Biochem. 2008, 383, 174-179.

  4. Sancho Solis, R.; Ge, Y.; Walker, J. W.* Single amino acid sequence polymorphisms in rat cardiac troponin revealed by top-down tandem mass spectrometry, J. Muscle Res. Cell Motil. 2008, 29, 203-212.

  5. Ma, M.; Chen, R.; Ge, Y.; He, H; Marshall, A. G.; Li, L.* Combining bottom-up and top-down mass spectrometric strategies for de novo sequencing of the Crustacean hyperglycemic hormone (CHH) from Cancer borealis, Anal. Chem. 2009, 81, 240-247.

  6. Wei, X.; Herbst, A.; Schmidt, J.; Aiken, J.; Li, L.* Facilitating discovery of prion disease biomarkers by quantitative glycoproteomics. LCGC, 2009 [Invited technical article, Accepted, to be appeared in March 2009 issue].

  7. Kuhn, P.; Xu, Q.; Cline, E.; Zhang, D.; Ge, Y.*; Xu, W.* Delineating Anopheles gambiae coactivator associated arginine methyltransferase 1 (AgCARM1) by top-down high resolution tandem mass spectrometry, Protein Sci. 2009, 18, 1272-1280.

  8. Liu, L.; Hou, J.; Du, J.; Chumanov, R. S. ; Xu, Q.; Ge, Y.; Johnson, J.A.; Murphy, R.M. Differential modification of Cys10 alters transthyretin’s effect on beta-amyloid aggregation and toxicity, Protein Eng. Des. Sel. 2009, 1–10.

  9. Ge, Y.*; Rybakova, I.; Xu, Q.; Moss, R. L. Top-down high resolution mass spectrometry of cardiac myosin binding protein C revealed that truncation alters protein phosphorylation state, Proc. Natl. Acad. Sci. U. S. A. 2009, Epub ahead of print.

  10. Ayaz-Guner, S.; Zhang, J.; Li, L.; Walker, J. W.*; Ge, Y.* In Vivo Phosphorylation Site Mapping in Mouse Cardiac Troponin I by High Resolution Top-Down Electron Capture Dissociation Mass Spectrometry: Ser22/23 Are the Only Sites Basally Phosphorylated, Biochemistry, 2009 Epub ahead of print.  

Selected Presentations:

  1. Ge, Y.; Zhao, D.; Gu, X.; Lemoff, A.S.; Ding, X. Rapid determination of disulfide bonds in large proteins by top down liquid chromatography tandem mass spectrometry, 54th Conf. Mass Spectrom. Allied Topics, Seattle, WA, 2006 (Poster Presentation)

  2. Ge, Y.; Walker, J.W.; Gumerov, D.R.; Easterling M.L.; Speir, J.P. Localization of phosphorylation sites in human cardiac troponin I by top down electron capture dissociation mass spectrometry, HUPO 5th World Congress, Long Beach, CA, 2006 (Oral Presentation)

  3. Ge, Y.; Zabrouskov, V.; Walker, J.W. Top Down Electron Capture Dissociation Mass Spectrometry for Characterization and Quantitative Determination of Phosphorylation in Human Cardiac Troponin I 6th NORTH AMERICAN FT-ICR MS CONFERENCE, Lake Tahoe, CA, 2007 (Poster Presentation).

  4. Zabrouskov, V.; Ge, Y.; Schwartz, J.; Walker, J.W. Unraveling molecular complexity of phosphorylated human cardiac troponin I by top down electron capture dissociation/electron transfer dissociation mass spectrometry HUPO 6th World Congress, Seoul, Korea, 2007 (Poster Presentation)

  5. Wei, X.; Schmidt, J.  A. Herbst, Aiken, J.; L. Li, Comparative glycoproteomics for the discovery of potential biomarkers for prion disease, 55th Conf. Mass Spectrom. Allied Topics, Indianapolis, IN, 2007, (Poster Presentation)

  6. Wei, X.; Schmidt, J.J.; Herbst, A.; Aiken, J.; Li, L. MS-based comparative profiling of glycoproteins for the discovery of potential biomarkers for prion disease, PittCon 2007, Chicago, IL (Poster Presentation)

  7. Ge, Y.; Xu, L.; Rybakova, I.; Zabrouskov, V.; Moss, R.L.; Walker, J.W. Top Down Disease Proteomics: Deciphering Protein Modifications for Understanding and Diagnosis of Human Diseases, 56th Conf. Mass Spectrom. Allied Topics, Denvor, CO, 2008 (Oral Presentation)

  8. L. Li, X. Wei, A. Herbst, S. McIlwain, J. Schmidt, R. Cunningham, D. Page, and J. Aiken, “Combining MALDI FTMS, comparative glycoproteomics, and bioinformatics for the discovery of biomarkers in prion disease,”  56th Conf. Mass Spectrom. Allied Topics, Denver, CO. 2008. (Oral Presentation)

  9. M. Ma, J. Schmidt, Y. Ge, L. Li, Mass spectrometric characterization of the crustacean hyperglycemic hormone (CHH) in the sinus gland of Cancer borealis, 56th Conf. Mass Spectrom. Allied Topics, Denver, CO. 2008, (Oral Presentation)

  10. Xu, W.  CARM1: modifications and functions, FASEB summer conference, Carefree, AZ, 2008. (Oral Presentation)

  11. Kuhn, P.; Xu, Q.; Cline, E.; Zhang, D.; Ge, Y.; Xu, W. Investigation of CARM1 automethylation by Top-Down Mass Spectrometry,  Molecular Basis for Chromatin Modifications and Epigenetic Phenomena,  Snowmass, Colorado, 2008. (Poster Presentation)

  12. Ge, Y. Top Down Disease Proteomics for Protein Biomarker Discovery and Validation, 6th Annual Protein Biomarker Summit, Philadelphia, PA, 2008.  (Invited Oral Presentation)

  13. Ge, Y.; Zhang, J.; Ayaz-Guner, S.; Xu, Q.; Rybakova, I.; Guy, M.; Young, K. H.; Walker, J. W.;   Moss, R. L. Top-down disease proteomics: deciphering myofilament protein modifications for understanding heart failure. ISHR North American Section Meeting, Baltimore, ML, 2009.

  14. Nelson, C. A.; Szezech, J. R.; Xu, Q.; Jin, S.; Ge, Y.  Mesoporous Metal Oxide Nanomaterials for Mass Spectrometry-based Phosphoproteomics, 57th Conf. Mass Spectrom. Allied Topics, Philadelphia, PA, 2009.

  15. Zhang, J.; Guy, M.; Xu, Q.; Salamat, M.S.; Young, K. H.; Walker, J. W.; Ge, Y.  Deciphering  Human Cardiac Troponin Modifications for Understanding and Diagnosis of Heart Failure: A Top-Down Mass Spectrometry-Based Disease Proteomics Approach, 57th Conf. Mass Spectrom. Allied Topics, Philadelphia, PA, 2009.

  16. Ayaz-Guner, S.; Doede, C.; Walker, J.W.; Ge, Y.Top-Down High Resolution Electron Capture Dissociation Mass spectrometry for Characterization of Post-Translational Modifications in Mouse Cardiac Troponin, 57th Conf. Mass Spectrom. Allied Topics, Philadelphia, PA, 2009.

  17. Kuhn, P.; Xu, Q.; Cline, E.; Zhang, D.; Ge, Y.; Xu, W. Top-down High Resolution Tandem Mass   Spectrometry for Characterization of Conserved Automethylation in Coactivator Associated Arginine Methyltransferase 1, 57th Conf. Mass Spectrom. Allied Topics, Philadelphia, PA, 2009.